Protein Phosphatase Classification: Asp-Based PSP/CIN※ CIN family introduction CIN, also known as Chronophin, belongs to a family of phosphatase which uses an Asp nucleophile for catalysis. CIN always colocalizes with F-actin and cofilin in membrane ruffles and lmellipodia. CIN can directly dephosphorylate cofilin, and involved cofilin-dependent actin cytoskeletal reorganization. CIN plays an important role in regulating cofilin-dependent cell division and normal cytoskinesis. CIN also possesses activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP) (1).
Reference
1.Gohla, A., Birkenfeld, J. and Bokoch, G.M. (2005) Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics. Nat Cell Biol, 7, 21-29. PMID: 15580268
Asp-Based PSP CIN in eukaryotes:
1.Gohla, A., Birkenfeld, J. and Bokoch, G.M. (2005) Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics. Nat Cell Biol, 7, 21-29. PMID: 15580268
Asp-Based PSP CIN in eukaryotes: