Ficedula albicollis      AGC/GRK


※ GRK family introduction

    GRK (G protein-coupled receptor (GPCR) kinase), belongs to the AGC group and is characterized by its role in relation with GPCR. GPCRs are multi-domain proteins, including an N-termainal unique region, a regulator of G protein signaling (RGS) homology domain (RH) and a kinase catalytic domain. The C-terminal domain is involved in their membrane targeting. GRK isoforms have been shown to target to specialized membrane compartments in specific cell types, which is suggested to have relation with their specific function. GRK is directly activated by docking with active GPCRs and GRK can phosphorylate the Serine/Threonine residue on active GPCR regulating downstream signaling. Besides GPCR, GRK can also mediate the phosphorylation of non-GPCR receptors including LRP6, PDGFRb, DREAM, NFkB1 and Nedd4 and involve in specific cellular processes or cell signaling cascade (1).

Reference
1. Gurevich, E.V., Tesmer, J.J., Mushegian, A. and Gurevich, V.V. (2012) G protein-coupled receptor kinases: more than just kinases and not only for GPCRs. Pharmacol Ther, 133, 40-69. PMID: 21903131


There are 6 genes.  Reviewed (0 or Unreviewed (6

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Fia-0362
ENSFALG00000012347.1
U3KD26
GRK2
2
iEKPD-Fia-0267
ENSFALG00000008603.1
U3K1T7
GRK3
3
iEKPD-Fia-0296
ENSFALG00000009786.1
U3K5B5
GRK4
4
iEKPD-Fia-0072
ENSFALG00000002184.1
U3JHM0
GRK5
5
iEKPD-Fia-0272
ENSFALG00000008751.1
U3K273
GRK6
6
iEKPD-Fia-0216
ENSFALG00000006983.1
U3JWY3
GRK7