※ GRK family introduction

    GRK (G protein-coupled receptor (GPCR) kinase), belongs to the AGC group and is characterized by its role in relation with GPCR. GPCRs are multi-domain proteins, including an N-termainal unique region, a regulator of G protein signaling (RGS) homology domain (RH) and a kinase catalytic domain. The C-terminal domain is involved in their membrane targeting. GRK isoforms have been shown to target to specialized membrane compartments in specific cell types, which is suggested to have relation with their specific function. GRK is directly activated by docking with active GPCRs and GRK can phosphorylate the Serine/Threonine residue on active GPCR regulating downstream signaling. Besides GPCR, GRK can also mediate the phosphorylation of non-GPCR receptors including LRP6, PDGFRb, DREAM, NFkB1 and Nedd4 and involve in specific cellular processes or cell signaling cascade (1).

Reference
1. Gurevich, E.V., Tesmer, J.J., Mushegian, A. and Gurevich, V.V. (2012) G protein-coupled receptor kinases: more than just kinases and not only for GPCRs. Pharmacol Ther, 133, 40-69. PMID: 21903131

  Reviewed (1)  or Unreviewed (6) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sus-0201	ENSSSCG00000011675.3	Q8WP15	GRK7
2		iEKPD-Sus-0149	ENSSSCG00000009562.2	F1RN35	GRK1
3		iEKPD-Sus-0224	ENSSSCG00000012918.3	F1RUX3	GRK2
4		iEKPD-Sus-0161	ENSSSCG00000009956.3	A0A287A1U2	GRK3
5		iEKPD-Sus-0132	ENSSSCG00000008694.3	F1S8P7	GRK4
6		iEKPD-Sus-0175	ENSSSCG00000010683.3	F1S417	GRK5
7		iEKPD-Sus-0431	ENSSSCG00000035028.1	A0A287AM21	GRK6