※ GRK family introduction

    GRK (G protein-coupled receptor (GPCR) kinase), belongs to the AGC group and is characterized by its role in relation with GPCR. GPCRs are multi-domain proteins, including an N-termainal unique region, a regulator of G protein signaling (RGS) homology domain (RH) and a kinase catalytic domain. The C-terminal domain is involved in their membrane targeting. GRK isoforms have been shown to target to specialized membrane compartments in specific cell types, which is suggested to have relation with their specific function. GRK is directly activated by docking with active GPCRs and GRK can phosphorylate the Serine/Threonine residue on active GPCR regulating downstream signaling. Besides GPCR, GRK can also mediate the phosphorylation of non-GPCR receptors including LRP6, PDGFRb, DREAM, NFkB1 and Nedd4 and involve in specific cellular processes or cell signaling cascade (1).

Reference
1. Gurevich, E.V., Tesmer, J.J., Mushegian, A. and Gurevich, V.V. (2012) G protein-coupled receptor kinases: more than just kinases and not only for GPCRs. Pharmacol Ther, 133, 40-69. PMID: 21903131

  Reviewed (0)  or Unreviewed (6) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Tag-0014	ENSTGUG00000000396.1	H0YQ60
2		iEKPD-Tag-0192	ENSTGUG00000006012.1	H0Z6Q4	GRK2
3		iEKPD-Tag-0243	ENSTGUG00000007559.1	H0ZB65	GRK3
4		iEKPD-Tag-0314	ENSTGUG00000010430.1	H0ZJL0	GRK4
5		iEKPD-Tag-0331	ENSTGUG00000011126.1	H0ZLL0	GRK5
6		iEKPD-Tag-0262	ENSTGUG00000008425.1	H0ZDL6	GRK7