※ MAST family introduction

    MASTs (Microtubule-associated Serine/Threonine-protein kinases) belong to AGC group. The MAST kinases are characterized by the presence of a Serine/Threonine kinase domain, a second 3' MAST domain and PDZ domain. The PDZ domain has been reported to mediate interaction with others proteins and help MAST to facilitate functionally important phosphorylation. The N-terminal kinase catalytic domain is relatively conserved in MAST family with a high identity (>60%). MAST family is expressed in multiple tissues. In nervous system, MAST may act as a key role through localization within the DAPC/UAPC, which is found within region of the neuromuscular junction (NMJ) and central synapses (1). Recently gene rearrangements involving MAST and Notch have been reported. Overexpression of MAST1 or MAST2 gene fusions plays an important effect on proliferative (2).

Reference
1. Garland, P., Quraishe, S., French, P. and O'Connor, V. (2008) Expression of the MAST family of serine/threonine kinases. Brain Res, 1195, 12-19. PMID: 18206861
2. Robinson, D.R., Kalyana-Sundaram, S., Wu, Y.M., Shankar, S., Cao, X., Ateeq, B., Asangani, I.A., Iyer, M., Maher, C.A., Grasso, C.S. et al. (2011) Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer. Nat Med, 17, 1646-1651 PMID: 22101766

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sem-1107	SELMODRAFT_89070	D8RB45	IRE1-1
2		iEKPD-Sem-0924	SELMODRAFT_451604	D8RHI1	IRE1-2
3		iEKPD-Sem-0099	SELMODRAFT_112057	D8S980	SELMODRAFT_112057
4		iEKPD-Sem-0188	SELMODRAFT_126061	D8SVM5	SELMODRAFT_126061