Bos taurus      AGC/PKA


※ PKA family introduction

    PKA (cAMP-dependent protein kinase) belongs to AGC group. PKA is characterized by its role as important downstream effecter of second messenger cAMP. PKA consists of multiple forms of regulatory and catalytic subunits and PKA holoenzyme contains two regulatory subunits and two catalytic subunits, which determines the biochemical and functional features. PKA keeps catalytically inactive under low levels of cAMP and PKA obtains its catalytic activity only after binding to the two binding sites on regulatory subunits. PKA involves in a varieties of cellular processes through phosphorylation of different nuclear and cytoplasmic substrates including metabolism, differentiation, synaptic transmission, ion channel activity, growth and development (1).

Reference
1. Feliciello, A., Gottesman, M.E. and Avvedimento, E.V. (2005) cAMP-PKA signaling to the mitochondria: protein scaffolds, mRNA and phosphatases. Cell Signal, 17, 279-287. PMID: 15567059


There are 3 genes.  Reviewed (2 or Unreviewed (1

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Bot-0115
ENSBTAG00000006642.4
P00517
PRKACA
2
iEKPD-Bot-0220
ENSBTAG00000011953.5
P05131
PRKACB
3
iEKPD-Bot-0266
ENSBTAG00000014367.5
F1N591
PRKX