※ PKA family introduction

    PKA (cAMP-dependent protein kinase) belongs to AGC group. PKA is characterized by its role as important downstream effecter of second messenger cAMP. PKA consists of multiple forms of regulatory and catalytic subunits and PKA holoenzyme contains two regulatory subunits and two catalytic subunits, which determines the biochemical and functional features. PKA keeps catalytically inactive under low levels of cAMP and PKA obtains its catalytic activity only after binding to the two binding sites on regulatory subunits. PKA involves in a varieties of cellular processes through phosphorylation of different nuclear and cytoplasmic substrates including metabolism, differentiation, synaptic transmission, ion channel activity, growth and development (1).

Reference
1. Feliciello, A., Gottesman, M.E. and Avvedimento, E.V. (2005) cAMP-PKA signaling to the mitochondria: protein scaffolds, mRNA and phosphatases. Cell Signal, 17, 279-287. PMID: 15567059

  Reviewed (0)  or Unreviewed (5) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Dar-0861	ENSDARG00000100349.1	A3KMS9	prkacaa
2		iEKPD-Dar-0119	ENSDARG00000016809.5	Q6DBV8	prkacab
3		iEKPD-Dar-0006	ENSDARG00000001782.10	Q7T374	prkacba
4		iEKPD-Dar-0400	ENSDARG00000059125.5	Q3ZB92	prkacbb
5		iEKPD-Dar-0419	ENSDARG00000060716.6	F1QN39	prkx