※ PKA family introduction

    PKA (cAMP-dependent protein kinase) belongs to AGC group. PKA is characterized by its role as important downstream effecter of second messenger cAMP. PKA consists of multiple forms of regulatory and catalytic subunits and PKA holoenzyme contains two regulatory subunits and two catalytic subunits, which determines the biochemical and functional features. PKA keeps catalytically inactive under low levels of cAMP and PKA obtains its catalytic activity only after binding to the two binding sites on regulatory subunits. PKA involves in a varieties of cellular processes through phosphorylation of different nuclear and cytoplasmic substrates including metabolism, differentiation, synaptic transmission, ion channel activity, growth and development (1).

Reference
1. Feliciello, A., Gottesman, M.E. and Avvedimento, E.V. (2005) cAMP-PKA signaling to the mitochondria: protein scaffolds, mRNA and phosphatases. Cell Signal, 17, 279-287. PMID: 15567059

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Mod-0252	ENSMODG00000012087.3	F7G4Q0	PRKACA
2		iEKPD-Mod-0009	ENSMODG00000000539.2	F6XMR1	PRKACB
3		iEKPD-Mod-0001	ENSMODG00000000005.3	F6SJ42	PRKX