※ PKA family introduction

    PKA (cAMP-dependent protein kinase) belongs to AGC group. PKA is characterized by its role as important downstream effecter of second messenger cAMP. PKA consists of multiple forms of regulatory and catalytic subunits and PKA holoenzyme contains two regulatory subunits and two catalytic subunits, which determines the biochemical and functional features. PKA keeps catalytically inactive under low levels of cAMP and PKA obtains its catalytic activity only after binding to the two binding sites on regulatory subunits. PKA involves in a varieties of cellular processes through phosphorylation of different nuclear and cytoplasmic substrates including metabolism, differentiation, synaptic transmission, ion channel activity, growth and development (1).

Reference
1. Feliciello, A., Gottesman, M.E. and Avvedimento, E.V. (2005) cAMP-PKA signaling to the mitochondria: protein scaffolds, mRNA and phosphatases. Cell Signal, 17, 279-287. PMID: 15567059

  Reviewed (0)  or Unreviewed (6) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Pat-0459	ENSPTRG00000045103.1	A0A2I3TK84
2		iEKPD-Pat-0193	ENSPTRG00000010585.5	H2QFK0	PRKACA
3		iEKPD-Pat-0017	ENSPTRG00000000899.6	H2R1G3	PRKACB
4		iEKPD-Pat-0397	ENSPTRG00000021003.3	H2QXB9	PRKACG
5		iEKPD-Pat-0420	ENSPTRG00000022476.4	H2QZC3	PRKX
6		iEKPD-Pat-0435	ENSPTRG00000038881.2	H2RI77	PRKY