※ PKA family introduction

    PKA (cAMP-dependent protein kinase) belongs to AGC group. PKA is characterized by its role as important downstream effecter of second messenger cAMP. PKA consists of multiple forms of regulatory and catalytic subunits and PKA holoenzyme contains two regulatory subunits and two catalytic subunits, which determines the biochemical and functional features. PKA keeps catalytically inactive under low levels of cAMP and PKA obtains its catalytic activity only after binding to the two binding sites on regulatory subunits. PKA involves in a varieties of cellular processes through phosphorylation of different nuclear and cytoplasmic substrates including metabolism, differentiation, synaptic transmission, ion channel activity, growth and development (1).

Reference
1. Feliciello, A., Gottesman, M.E. and Avvedimento, E.V. (2005) cAMP-PKA signaling to the mitochondria: protein scaffolds, mRNA and phosphatases. Cell Signal, 17, 279-287. PMID: 15567059

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Php-0523	PP1S36_201V6
2		iEKPD-Php-0681	PP1S59_88V6	A9S9X2	PHYPADRAFT_126373
3		iEKPD-Php-0725	PP1S69_82V6	A9SDZ8	PHYPADRAFT_128348
4		iEKPD-Php-1295	PP1S81_123V6	A9SIB5	PHYPADRAFT_185240
5		iEKPD-Php-1296	PP1S88_186V6	A9SKP4	PHYPADRAFT_185987