※ PKA family introduction

    PKA (cAMP-dependent protein kinase) belongs to AGC group. PKA is characterized by its role as important downstream effecter of second messenger cAMP. PKA consists of multiple forms of regulatory and catalytic subunits and PKA holoenzyme contains two regulatory subunits and two catalytic subunits, which determines the biochemical and functional features. PKA keeps catalytically inactive under low levels of cAMP and PKA obtains its catalytic activity only after binding to the two binding sites on regulatory subunits. PKA involves in a varieties of cellular processes through phosphorylation of different nuclear and cytoplasmic substrates including metabolism, differentiation, synaptic transmission, ion channel activity, growth and development (1).

Reference
1. Feliciello, A., Gottesman, M.E. and Avvedimento, E.V. (2005) cAMP-PKA signaling to the mitochondria: protein scaffolds, mRNA and phosphatases. Cell Signal, 17, 279-287. PMID: 15567059

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sem-0074	SELMODRAFT_110120	D8S6E1	SELMODRAFT_110120
2		iEKPD-Sem-0176	SELMODRAFT_124622	D8STQ5	SELMODRAFT_124622
3		iEKPD-Sem-0274	SELMODRAFT_137987	D8TEH6	SELMODRAFT_137987
4		iEKPD-Sem-1907	SELMODRAFT_440463	D8RBZ0	SELMODRAFT_440463
5		iEKPD-Sem-1909	SELMODRAFT_443005	D8RXN3	SELMODRAFT_443005
6		iEKPD-Sem-1159	SELMODRAFT_99275	D8RQF6	SELMODRAFT_99275