※ PKA family introduction

    PKA (cAMP-dependent protein kinase) belongs to AGC group. PKA is characterized by its role as important downstream effecter of second messenger cAMP. PKA consists of multiple forms of regulatory and catalytic subunits and PKA holoenzyme contains two regulatory subunits and two catalytic subunits, which determines the biochemical and functional features. PKA keeps catalytically inactive under low levels of cAMP and PKA obtains its catalytic activity only after binding to the two binding sites on regulatory subunits. PKA involves in a varieties of cellular processes through phosphorylation of different nuclear and cytoplasmic substrates including metabolism, differentiation, synaptic transmission, ion channel activity, growth and development (1).

Reference
1. Feliciello, A., Gottesman, M.E. and Avvedimento, E.V. (2005) cAMP-PKA signaling to the mitochondria: protein scaffolds, mRNA and phosphatases. Cell Signal, 17, 279-287. PMID: 15567059

  Reviewed (0)  or Unreviewed (5) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sus-0222	ENSSSCG00000012833.3	A0A287ANG8
2		iEKPD-Sus-0405	ENSSSCG00000031521.1	A0A287AWE4
3		iEKPD-Sus-0238	ENSSSCG00000013771.3	F1SD45	PRKACA
4		iEKPD-Sus-0476	ENSSSCG00000040920.1	A0A286ZLZ0	PRKACB
5		iEKPD-Sus-0459	ENSSSCG00000038963.1	A0A286ZVI4	PRKX