※ PKC family introduction

    PKC (protein kinase C) belongs to AGC group. PKC can be grouped into three sections based on similar structural and activation requirements: classical, novel and atypical. Classical PKCs are activated by calcium, phosphatidylserine and diacylglycerol or phorbol esters. The novel PKCs lack a conserved region found in classical PKC and is activated by different lipids. The atypical PKCs is smallest in size in all PKCs which are activated by PS. PKCs keep an inactive state in the cytosol and translocate to the membrane vesicles, nuclear structures and cytoskeletal components after cell stimulation. Activated PKCs have been shown to involve in a varieties cellular processes including receptor desensitization, transcription, immune responses and cell growth (1).

Reference
1. Keenan, C. and Kelleher, D. (1998) Protein kinase C and the cytoskeleton. Cell Signal, 10, 225-232. PMID: 9617479

  Reviewed (0)  or Unreviewed (9) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Anp-0173	ENSAPLG00000007620.1	U3IJ49
2		iEKPD-Anp-0060	ENSAPLG00000003675.1	U3I7D8	LOC101794101
3		iEKPD-Anp-0213	ENSAPLG00000009329.1	U3IPH6	PRKCA
4		iEKPD-Anp-0203	ENSAPLG00000008998.1	U3IN81	PRKCB
5		iEKPD-Anp-0025	ENSAPLG00000002693.1	U3I4L8	PRKCD
6		iEKPD-Anp-0147	ENSAPLG00000006475.1	U3IFU8	PRKCE
7		iEKPD-Anp-0190	ENSAPLG00000008398.1	U3ILM2	PRKCI
8		iEKPD-Anp-1109	ENSAPLG00000013073.1	U3J095	PRKCQ
9		iEKPD-Anp-0239	ENSAPLG00000010027.1	U3IRA8	PRKCZ