※ PKC family introduction

    PKC (protein kinase C) belongs to AGC group. PKC can be grouped into three sections based on similar structural and activation requirements: classical, novel and atypical. Classical PKCs are activated by calcium, phosphatidylserine and diacylglycerol or phorbol esters. The novel PKCs lack a conserved region found in classical PKC and is activated by different lipids. The atypical PKCs is smallest in size in all PKCs which are activated by PS. PKCs keep an inactive state in the cytosol and translocate to the membrane vesicles, nuclear structures and cytoskeletal components after cell stimulation. Activated PKCs have been shown to involve in a varieties cellular processes including receptor desensitization, transcription, immune responses and cell growth (1).

Reference
1. Keenan, C. and Kelleher, D. (1998) Protein kinase C and the cytoskeleton. Cell Signal, 10, 225-232. PMID: 9617479

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Anc-0017	ENSACAG00000000629.3	H9G4Z4	PRKCA
2		iEKPD-Anc-1227	ENSACAG00000008408.3	G1KHZ5	PRKCD
3		iEKPD-Anc-0089	ENSACAG00000003872.3	H9G8C8	PRKCE
4		iEKPD-Anc-0397	ENSACAG00000016368.3	H9GNA6	PRKCG
5		iEKPD-Anc-0139	ENSACAG00000006398.3	G1KFF4	PRKCH
6		iEKPD-Anc-0387	ENSACAG00000015906.3	G1KRY6	PRKCI
7		iEKPD-Anc-0114	ENSACAG00000005073.3	G1KDN6	PRKCQ