Bos taurus      AGC/PKC


※ PKC family introduction

    PKC (protein kinase C) belongs to AGC group. PKC can be grouped into three sections based on similar structural and activation requirements: classical, novel and atypical. Classical PKCs are activated by calcium, phosphatidylserine and diacylglycerol or phorbol esters. The novel PKCs lack a conserved region found in classical PKC and is activated by different lipids. The atypical PKCs is smallest in size in all PKCs which are activated by PS. PKCs keep an inactive state in the cytosol and translocate to the membrane vesicles, nuclear structures and cytoskeletal components after cell stimulation. Activated PKCs have been shown to involve in a varieties cellular processes including receptor desensitization, transcription, immune responses and cell growth (1).

Reference
1. Keenan, C. and Kelleher, D. (1998) Protein kinase C and the cytoskeleton. Cell Signal, 10, 225-232. PMID: 9617479


There are 10 genes.  Reviewed (2 or Unreviewed (8

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Bot-0394
ENSBTAG00000020921.5
P05126
PRKCB
2
iEKPD-Bot-0250
ENSBTAG00000013550.5
P05128
PRKCG
3
iEKPD-Bot-0290
ENSBTAG00000015409.4
F1MJA3
4
iEKPD-Bot-0024
ENSBTAG00000001061.5
F1MJX9
PRKCA
5
iEKPD-Bot-1248
ENSBTAG00000008719.5
F1MZX0
PRKCD
6
iEKPD-Bot-0386
ENSBTAG00000020614.5
F1MDC9
PRKCE
7
iEKPD-Bot-0060
ENSBTAG00000003276.4
F1MY82
PRKCH
8
iEKPD-Bot-0029
ENSBTAG00000001403.6
F1MQ96
PRKCI
9
iEKPD-Bot-1250
ENSBTAG00000010664.6
E1BMG4
PRKCQ
10
iEKPD-Bot-0262
ENSBTAG00000014119.5
A0JNH7
PRKCZ