※ PKC family introduction

    PKC (protein kinase C) belongs to AGC group. PKC can be grouped into three sections based on similar structural and activation requirements: classical, novel and atypical. Classical PKCs are activated by calcium, phosphatidylserine and diacylglycerol or phorbol esters. The novel PKCs lack a conserved region found in classical PKC and is activated by different lipids. The atypical PKCs is smallest in size in all PKCs which are activated by PS. PKCs keep an inactive state in the cytosol and translocate to the membrane vesicles, nuclear structures and cytoskeletal components after cell stimulation. Activated PKCs have been shown to involve in a varieties cellular processes including receptor desensitization, transcription, immune responses and cell growth (1).

Reference
1. Keenan, C. and Kelleher, D. (1998) Protein kinase C and the cytoskeleton. Cell Signal, 10, 225-232. PMID: 9617479

  Reviewed (0)  or Unreviewed (9) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Caj-0005	ENSCJAG00000000333.2	F7GMK8	PRKCA
2		iEKPD-Caj-0431	ENSCJAG00000020643.2	F7I4L6	PRKCB
3		iEKPD-Caj-1269	ENSCJAG00000007197.2	F6ZHC0	PRKCD
4		iEKPD-Caj-0012	ENSCJAG00000000724.2	F6U9Y6	PRKCE
5		iEKPD-Caj-0394	ENSCJAG00000018393.2	F7GJ11	PRKCG
6		iEKPD-Caj-0405	ENSCJAG00000019178.2	F7HD36	PRKCH
7		iEKPD-Caj-0053	ENSCJAG00000002470.3	F7C4A7	PRKCI
8		iEKPD-Caj-1293	ENSCJAG00000020594.2	F7IL85	PRKCQ
9		iEKPD-Caj-0052	ENSCJAG00000002409.3	F6YNM4	PRKCZ