※ PKC family introduction

    PKC (protein kinase C) belongs to AGC group. PKC can be grouped into three sections based on similar structural and activation requirements: classical, novel and atypical. Classical PKCs are activated by calcium, phosphatidylserine and diacylglycerol or phorbol esters. The novel PKCs lack a conserved region found in classical PKC and is activated by different lipids. The atypical PKCs is smallest in size in all PKCs which are activated by PS. PKCs keep an inactive state in the cytosol and translocate to the membrane vesicles, nuclear structures and cytoskeletal components after cell stimulation. Activated PKCs have been shown to involve in a varieties cellular processes including receptor desensitization, transcription, immune responses and cell growth (1).

Reference
1. Keenan, C. and Kelleher, D. (1998) Protein kinase C and the cytoskeleton. Cell Signal, 10, 225-232. PMID: 9617479

  Reviewed (0)  or Unreviewed (9) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Caf-0243	ENSCAFG00000011326.3	F1Q1D5	PRKCA
2		iEKPD-Caf-0380	ENSCAFG00000017622.3	F1PKU7	PRKCB
3		iEKPD-Caf-1267	ENSCAFG00000008689.3	F1PDX2	PRKCD
4		iEKPD-Caf-0059	ENSCAFG00000002610.3	F1PMX4	PRKCE
5		iEKPD-Caf-0060	ENSCAFG00000002713.4	E2R2X3	PRKCG
6		iEKPD-Caf-0339	ENSCAFG00000015695.4	E2RGU7	PRKCH
7		iEKPD-Caf-0319	ENSCAFG00000014823.3	F1PG28	PRKCI
8		iEKPD-Caf-1259	ENSCAFG00000005169.3	E2RNP2	PRKCQ
9		iEKPD-Caf-0426	ENSCAFG00000019381.3	F6XMN6	PRKCZ