Cercocebus atys      AGC/PKC


※ PKC family introduction

    PKC (protein kinase C) belongs to AGC group. PKC can be grouped into three sections based on similar structural and activation requirements: classical, novel and atypical. Classical PKCs are activated by calcium, phosphatidylserine and diacylglycerol or phorbol esters. The novel PKCs lack a conserved region found in classical PKC and is activated by different lipids. The atypical PKCs is smallest in size in all PKCs which are activated by PS. PKCs keep an inactive state in the cytosol and translocate to the membrane vesicles, nuclear structures and cytoskeletal components after cell stimulation. Activated PKCs have been shown to involve in a varieties cellular processes including receptor desensitization, transcription, immune responses and cell growth (1).

Reference
1. Keenan, C. and Kelleher, D. (1998) Protein kinase C and the cytoskeleton. Cell Signal, 10, 225-232. PMID: 9617479


There are 9 genes.  Reviewed (0 or Unreviewed (9

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Cea-0050
ENSCATG00000016302.1
2
iEKPD-Cea-0091
ENSCATG00000025809.1
3
iEKPD-Cea-0144
ENSCATG00000031179.1
4
iEKPD-Cea-0186
ENSCATG00000032869.1
5
iEKPD-Cea-0224
ENSCATG00000034289.1
6
iEKPD-Cea-1305
ENSCATG00000034698.1
7
iEKPD-Cea-1308
ENSCATG00000034950.1
8
iEKPD-Cea-0268
ENSCATG00000036251.1
9
iEKPD-Cea-0381
ENSCATG00000040854.1