※ PKC family introduction

    PKC (protein kinase C) belongs to AGC group. PKC can be grouped into three sections based on similar structural and activation requirements: classical, novel and atypical. Classical PKCs are activated by calcium, phosphatidylserine and diacylglycerol or phorbol esters. The novel PKCs lack a conserved region found in classical PKC and is activated by different lipids. The atypical PKCs is smallest in size in all PKCs which are activated by PS. PKCs keep an inactive state in the cytosol and translocate to the membrane vesicles, nuclear structures and cytoskeletal components after cell stimulation. Activated PKCs have been shown to involve in a varieties cellular processes including receptor desensitization, transcription, immune responses and cell growth (1).

Reference
1. Keenan, C. and Kelleher, D. (1998) Protein kinase C and the cytoskeleton. Cell Signal, 10, 225-232. PMID: 9617479

  Reviewed (0)  or Unreviewed (9) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Dio-0220	ENSDORG00000010223.2	A0A1S3GXB8	Prkca
2		iEKPD-Dio-0364	ENSDORG00000015927.2	A0A1S3EQF8	Prkcb
3		iEKPD-Dio-1181	ENSDORG00000014718.2	A0A1S3GE11	Prkcd
4		iEKPD-Dio-0226	ENSDORG00000010474.2	A0A1S3FAS7	Prkce
5		iEKPD-Dio-0091	ENSDORG00000003929.2	A0A1S3G3I1	Prkcg
6		iEKPD-Dio-0353	ENSDORG00000015119.2	A0A1S3EZF8	Prkch
7		iEKPD-Dio-0330	ENSDORG00000014568.2	A0A1S3F5T2	Prkci
8		iEKPD-Dio-1183	ENSDORG00000015923.2	A0A1S3EKE5	Prkcq
9		iEKPD-Dio-0358	ENSDORG00000015442.2	A0A1S3GDH1	Prkcz