Felis catus      AGC/PKC


※ PKC family introduction

    PKC (protein kinase C) belongs to AGC group. PKC can be grouped into three sections based on similar structural and activation requirements: classical, novel and atypical. Classical PKCs are activated by calcium, phosphatidylserine and diacylglycerol or phorbol esters. The novel PKCs lack a conserved region found in classical PKC and is activated by different lipids. The atypical PKCs is smallest in size in all PKCs which are activated by PS. PKCs keep an inactive state in the cytosol and translocate to the membrane vesicles, nuclear structures and cytoskeletal components after cell stimulation. Activated PKCs have been shown to involve in a varieties cellular processes including receptor desensitization, transcription, immune responses and cell growth (1).

Reference
1. Keenan, C. and Kelleher, D. (1998) Protein kinase C and the cytoskeleton. Cell Signal, 10, 225-232. PMID: 9617479


There are 9 genes.  Reviewed (0 or Unreviewed (9

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Fec-0223
ENSFCAG00000012011.4
M3WG61
PRKCA
2
iEKPD-Fec-0211
ENSFCAG00000011124.4
A0A2I2U7E2
PRKCB
3
iEKPD-Fec-1235
ENSFCAG00000003900.4
M3W161
PRKCD
4
iEKPD-Fec-0105
ENSFCAG00000005102.4
A0A2I2USU9
PRKCE
5
iEKPD-Fec-0028
ENSFCAG00000001566.4
M3VWV6
PRKCG
6
iEKPD-Fec-0245
ENSFCAG00000012900.4
M3WHU4
PRKCH
7
iEKPD-Fec-0379
ENSFCAG00000026908.2
M3XF13
PRKCI
8
iEKPD-Fec-1249
ENSFCAG00000009472.4
A0A2I2UL73
PRKCQ
9
iEKPD-Fec-0123
ENSFCAG00000006209.3
M3W5H7
PRKCZ