Gallus gallus      AGC/PKC


※ PKC family introduction

    PKC (protein kinase C) belongs to AGC group. PKC can be grouped into three sections based on similar structural and activation requirements: classical, novel and atypical. Classical PKCs are activated by calcium, phosphatidylserine and diacylglycerol or phorbol esters. The novel PKCs lack a conserved region found in classical PKC and is activated by different lipids. The atypical PKCs is smallest in size in all PKCs which are activated by PS. PKCs keep an inactive state in the cytosol and translocate to the membrane vesicles, nuclear structures and cytoskeletal components after cell stimulation. Activated PKCs have been shown to involve in a varieties cellular processes including receptor desensitization, transcription, immune responses and cell growth (1).

Reference
1. Keenan, C. and Kelleher, D. (1998) Protein kinase C and the cytoskeleton. Cell Signal, 10, 225-232. PMID: 9617479


There are 7 genes.  Reviewed (0 or Unreviewed (7

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Gag-0160
ENSGALG00000010000.5
F1NG47
2
iEKPD-Gag-0197
ENSGALG00000011889.5
F1NJH1
3
iEKPD-Gag-0284
ENSGALG00000025950.2
R4GHL2
PRKCA
4
iEKPD-Gag-0377
ENSGALG00000037943.1
A0A1D5PUY5
PRKCB
5
iEKPD-Gag-0143
ENSGALG00000009364.6
E1BWA3
PRKCI
6
iEKPD-Gag-1201
ENSGALG00000034970.1
A0A1D5NUL7
PRKCQ
7
iEKPD-Gag-0016
ENSGALG00000001270.5
E1BQN6
PRKCZ