※ PKC family introduction

    PKC (protein kinase C) belongs to AGC group. PKC can be grouped into three sections based on similar structural and activation requirements: classical, novel and atypical. Classical PKCs are activated by calcium, phosphatidylserine and diacylglycerol or phorbol esters. The novel PKCs lack a conserved region found in classical PKC and is activated by different lipids. The atypical PKCs is smallest in size in all PKCs which are activated by PS. PKCs keep an inactive state in the cytosol and translocate to the membrane vesicles, nuclear structures and cytoskeletal components after cell stimulation. Activated PKCs have been shown to involve in a varieties cellular processes including receptor desensitization, transcription, immune responses and cell growth (1).

Reference
1. Keenan, C. and Kelleher, D. (1998) Protein kinase C and the cytoskeleton. Cell Signal, 10, 225-232. PMID: 9617479

  Reviewed (0)  or Unreviewed (9) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Loa-0118	ENSLAFG00000005785.3	G3SWW4	PRKCA
2		iEKPD-Loa-0022	ENSLAFG00000001035.3	G3SMU4	PRKCB
3		iEKPD-Loa-1259	ENSLAFG00000015864.2	G3TVL9	PRKCD
4		iEKPD-Loa-0116	ENSLAFG00000005726.3	G3SWS9	PRKCE
5		iEKPD-Loa-0292	ENSLAFG00000014284.3	G3U102	PRKCG
6		iEKPD-Loa-0218	ENSLAFG00000010349.3	G3T5F9	PRKCH
7		iEKPD-Loa-0092	ENSLAFG00000004925.4	G3SV72	PRKCI
8		iEKPD-Loa-1226	ENSLAFG00000001626.3	G3SNX2	PRKCQ
9		iEKPD-Loa-0383	ENSLAFG00000018460.3	G3TKV6	PRKCZ