※ PKC family introduction

    PKC (protein kinase C) belongs to AGC group. PKC can be grouped into three sections based on similar structural and activation requirements: classical, novel and atypical. Classical PKCs are activated by calcium, phosphatidylserine and diacylglycerol or phorbol esters. The novel PKCs lack a conserved region found in classical PKC and is activated by different lipids. The atypical PKCs is smallest in size in all PKCs which are activated by PS. PKCs keep an inactive state in the cytosol and translocate to the membrane vesicles, nuclear structures and cytoskeletal components after cell stimulation. Activated PKCs have been shown to involve in a varieties cellular processes including receptor desensitization, transcription, immune responses and cell growth (1).

Reference
1. Keenan, C. and Kelleher, D. (1998) Protein kinase C and the cytoskeleton. Cell Signal, 10, 225-232. PMID: 9617479

  Reviewed (0)  or Unreviewed (6) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Mel-0050	MELLADRAFT_31149	F4R8H9	MELLADRAFT_31149
2		iEKPD-Mel-0135	MELLADRAFT_85936	F4RK76	MELLADRAFT_85936
3		iEKPD-Mel-0139	MELLADRAFT_87261	F4SDS7	MELLADRAFT_87261
4		iEKPD-Mel-0171	MELLADRAFT_93332	F4S4T4	MELLADRAFT_93332
5		iEKPD-Mel-0176	MELLADRAFT_94151	F4S6N5	MELLADRAFT_94151
6		iEKPD-Mel-0183	MELLADRAFT_96356	F4REH1	MELLADRAFT_96356