※ PKC family introduction

    PKC (protein kinase C) belongs to AGC group. PKC can be grouped into three sections based on similar structural and activation requirements: classical, novel and atypical. Classical PKCs are activated by calcium, phosphatidylserine and diacylglycerol or phorbol esters. The novel PKCs lack a conserved region found in classical PKC and is activated by different lipids. The atypical PKCs is smallest in size in all PKCs which are activated by PS. PKCs keep an inactive state in the cytosol and translocate to the membrane vesicles, nuclear structures and cytoskeletal components after cell stimulation. Activated PKCs have been shown to involve in a varieties cellular processes including receptor desensitization, transcription, immune responses and cell growth (1).

Reference
1. Keenan, C. and Kelleher, D. (1998) Protein kinase C and the cytoskeleton. Cell Signal, 10, 225-232. PMID: 9617479

  Reviewed (0)  or Unreviewed (8) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Mim-0034	ENSMICG00000002219.3
2		iEKPD-Mim-0154	ENSMICG00000007855.3
3		iEKPD-Mim-0159	ENSMICG00000008028.3
4		iEKPD-Mim-1259	ENSMICG00000010903.3
5		iEKPD-Mim-1260	ENSMICG00000011435.3
6		iEKPD-Mim-0256	ENSMICG00000013171.3
7		iEKPD-Mim-0259	ENSMICG00000013271.3
8		iEKPD-Mim-0304	ENSMICG00000015697.3