※ PKC family introduction

    PKC (protein kinase C) belongs to AGC group. PKC can be grouped into three sections based on similar structural and activation requirements: classical, novel and atypical. Classical PKCs are activated by calcium, phosphatidylserine and diacylglycerol or phorbol esters. The novel PKCs lack a conserved region found in classical PKC and is activated by different lipids. The atypical PKCs is smallest in size in all PKCs which are activated by PS. PKCs keep an inactive state in the cytosol and translocate to the membrane vesicles, nuclear structures and cytoskeletal components after cell stimulation. Activated PKCs have been shown to involve in a varieties cellular processes including receptor desensitization, transcription, immune responses and cell growth (1).

Reference
1. Keenan, C. and Kelleher, D. (1998) Protein kinase C and the cytoskeleton. Cell Signal, 10, 225-232. PMID: 9617479

  Reviewed (0)  or Unreviewed (11) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Mod-0442	ENSMODG00000022776.2	H9H8W3
2		iEKPD-Mod-0451	ENSMODG00000024996.1	F6TU13
3		iEKPD-Mod-0452	ENSMODG00000024997.2	F6TTK9
4		iEKPD-Mod-g010	ENSMODG00000000928.3	F7F827
5		iEKPD-Mod-0081	ENSMODG00000004147.3	F6RA79	PRKCA
6		iEKPD-Mod-0344	ENSMODG00000016311.3	F7A632	PRKCB
7		iEKPD-Mod-1260	ENSMODG00000010650.3	F7D467	PRKCD
8		iEKPD-Mod-0170	ENSMODG00000008706.3	F6PWG0	PRKCH
9		iEKPD-Mod-0338	ENSMODG00000016076.3	F7G9R7	PRKCI
10		iEKPD-Mod-1266	ENSMODG00000016663.3	F7G6Y7	PRKCQ
11		iEKPD-Mod-0428	ENSMODG00000020916.3	H9H7S7	PRKCZ