※ PKC family introduction

    PKC (protein kinase C) belongs to AGC group. PKC can be grouped into three sections based on similar structural and activation requirements: classical, novel and atypical. Classical PKCs are activated by calcium, phosphatidylserine and diacylglycerol or phorbol esters. The novel PKCs lack a conserved region found in classical PKC and is activated by different lipids. The atypical PKCs is smallest in size in all PKCs which are activated by PS. PKCs keep an inactive state in the cytosol and translocate to the membrane vesicles, nuclear structures and cytoskeletal components after cell stimulation. Activated PKCs have been shown to involve in a varieties cellular processes including receptor desensitization, transcription, immune responses and cell growth (1).

Reference
1. Keenan, C. and Kelleher, D. (1998) Protein kinase C and the cytoskeleton. Cell Signal, 10, 225-232. PMID: 9617479

  Reviewed (0)  or Unreviewed (9) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Myl-0141	ENSMLUG00000006267.2	G1P6M6
2		iEKPD-Myl-0463	ENSMLUG00000028914.1	G1Q1U2
3		iEKPD-Myl-0033	ENSMLUG00000001590.2	G1NVY6	PRKCA
4		iEKPD-Myl-0158	ENSMLUG00000006872.2	G1P813	PRKCB
5		iEKPD-Myl-1230	ENSMLUG00000000929.2	G1NUF9	PRKCD
6		iEKPD-Myl-0163	ENSMLUG00000007061.2	G1P8G3	PRKCE
7		iEKPD-Myl-0361	ENSMLUG00000015500.2	G1PSH7	PRKCG
8		iEKPD-Myl-0079	ENSMLUG00000003390.2	G1P016	PRKCH
9		iEKPD-Myl-1234	ENSMLUG00000004034.2	G1P1I5	PRKCQ