※ PKC family introduction

    PKC (protein kinase C) belongs to AGC group. PKC can be grouped into three sections based on similar structural and activation requirements: classical, novel and atypical. Classical PKCs are activated by calcium, phosphatidylserine and diacylglycerol or phorbol esters. The novel PKCs lack a conserved region found in classical PKC and is activated by different lipids. The atypical PKCs is smallest in size in all PKCs which are activated by PS. PKCs keep an inactive state in the cytosol and translocate to the membrane vesicles, nuclear structures and cytoskeletal components after cell stimulation. Activated PKCs have been shown to involve in a varieties cellular processes including receptor desensitization, transcription, immune responses and cell growth (1).

Reference
1. Keenan, C. and Kelleher, D. (1998) Protein kinase C and the cytoskeleton. Cell Signal, 10, 225-232. PMID: 9617479

  Reviewed (0)  or Unreviewed (11) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Ora-0027	ENSOANG00000001477.2	F7F1W5
2		iEKPD-Ora-0093	ENSOANG00000004136.2	F7A182
3		iEKPD-Ora-0235	ENSOANG00000010041.2	F6W9R5
4		iEKPD-Ora-0423	ENSOANG00000028300.1	K7EHE7
5		iEKPD-Ora-0432	ENSOANG00000028716.1	K7E724
6		iEKPD-Ora-g033	ENSOANG00000028287.1	K7ECM2
7		iEKPD-Ora-g025	ENSOANG00000030579.1	K7ED72
8		iEKPD-Ora-0005	ENSOANG00000000308.2	F7EGB8	LOC100077834
9		iEKPD-Ora-0173	ENSOANG00000008060.2	F7CUS9	PRKCA
10		iEKPD-Ora-0211	ENSOANG00000009091.2	F7G7C3	PRKCH
11		iEKPD-Ora-1175	ENSOANG00000015452.2	F6PVR3	PRKCQ