※ PKC family introduction

    PKC (protein kinase C) belongs to AGC group. PKC can be grouped into three sections based on similar structural and activation requirements: classical, novel and atypical. Classical PKCs are activated by calcium, phosphatidylserine and diacylglycerol or phorbol esters. The novel PKCs lack a conserved region found in classical PKC and is activated by different lipids. The atypical PKCs is smallest in size in all PKCs which are activated by PS. PKCs keep an inactive state in the cytosol and translocate to the membrane vesicles, nuclear structures and cytoskeletal components after cell stimulation. Activated PKCs have been shown to involve in a varieties cellular processes including receptor desensitization, transcription, immune responses and cell growth (1).

Reference
1. Keenan, C. and Kelleher, D. (1998) Protein kinase C and the cytoskeleton. Cell Signal, 10, 225-232. PMID: 9617479

  Reviewed (0)  or Unreviewed (9) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Otg-0325	ENSOGAG00000013623.2	H0X9H1	PRKCA
2		iEKPD-Otg-0025	ENSOGAG00000001199.2	H0WI40	PRKCB
3		iEKPD-Otg-1269	ENSOGAG00000004030.2	H0WP04	PRKCD
4		iEKPD-Otg-0179	ENSOGAG00000008081.2	H0WXN6	PRKCE
5		iEKPD-Otg-0176	ENSOGAG00000007961.2	B5FWA6	PRKCG
6		iEKPD-Otg-0378	ENSOGAG00000016105.2	H0XEN0	PRKCH
7		iEKPD-Otg-0124	ENSOGAG00000005563.2	H0WSB9	PRKCI
8		iEKPD-Otg-1294	ENSOGAG00000013168.2	H0X8H6	PRKCQ
9		iEKPD-Otg-0031	ENSOGAG00000001629.2	H0WJ10	PRKCZ