Pan paniscus      AGC/PKC


※ PKC family introduction

    PKC (protein kinase C) belongs to AGC group. PKC can be grouped into three sections based on similar structural and activation requirements: classical, novel and atypical. Classical PKCs are activated by calcium, phosphatidylserine and diacylglycerol or phorbol esters. The novel PKCs lack a conserved region found in classical PKC and is activated by different lipids. The atypical PKCs is smallest in size in all PKCs which are activated by PS. PKCs keep an inactive state in the cytosol and translocate to the membrane vesicles, nuclear structures and cytoskeletal components after cell stimulation. Activated PKCs have been shown to involve in a varieties cellular processes including receptor desensitization, transcription, immune responses and cell growth (1).

Reference
1. Keenan, C. and Kelleher, D. (1998) Protein kinase C and the cytoskeleton. Cell Signal, 10, 225-232. PMID: 9617479


There are 10 genes.  Reviewed (0 or Unreviewed (10

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Pap-1285
ENSPPAG00000028635.1
2
iEKPD-Pap-0133
ENSPPAG00000029801.1
3
iEKPD-Pap-0178
ENSPPAG00000031670.1
4
iEKPD-Pap-0203
ENSPPAG00000032966.1
5
iEKPD-Pap-0207
ENSPPAG00000033245.1
6
iEKPD-Pap-1294
ENSPPAG00000033532.1
7
iEKPD-Pap-0221
ENSPPAG00000034072.1
8
iEKPD-Pap-0233
ENSPPAG00000034428.1
9
iEKPD-Pap-0323
ENSPPAG00000037360.1
10
iEKPD-Pap-0445
ENSPPAG00000042720.1