※ PKC family introduction

    PKC (protein kinase C) belongs to AGC group. PKC can be grouped into three sections based on similar structural and activation requirements: classical, novel and atypical. Classical PKCs are activated by calcium, phosphatidylserine and diacylglycerol or phorbol esters. The novel PKCs lack a conserved region found in classical PKC and is activated by different lipids. The atypical PKCs is smallest in size in all PKCs which are activated by PS. PKCs keep an inactive state in the cytosol and translocate to the membrane vesicles, nuclear structures and cytoskeletal components after cell stimulation. Activated PKCs have been shown to involve in a varieties cellular processes including receptor desensitization, transcription, immune responses and cell growth (1).

Reference
1. Keenan, C. and Kelleher, D. (1998) Protein kinase C and the cytoskeleton. Cell Signal, 10, 225-232. PMID: 9617479

  Reviewed (0)  or Unreviewed (10) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Pat-0469	ENSPTRG00000046709.1	A0A2I3SQA3
2		iEKPD-Pat-0501	ENSPTRG00000052745.1	A0A2I3TAE2
3		iEKPD-Pat-0176	ENSPTRG00000009557.7	H2QDQ1	PRKCA
4		iEKPD-Pat-0144	ENSPTRG00000007895.7	H2QAS6	PRKCB
5		iEKPD-Pat-1361	ENSPTRG00000015023.5	K7DA70	PRKCD
6		iEKPD-Pat-0221	ENSPTRG00000011890.6	K7CBH8	PRKCE
7		iEKPD-Pat-0209	ENSPTRG00000011435.4	H2QH30	PRKCG
8		iEKPD-Pat-0112	ENSPTRG00000006418.3	H2Q8F2	PRKCH
9		iEKPD-Pat-0289	ENSPTRG00000015615.7	A0A2I3RQJ8	PRKCI
10		iEKPD-Pat-1345	ENSPTRG00000002270.6	A0A2I3SR38	PRKCQ