Pelodiscus sinensis      AGC/PKC


※ PKC family introduction

    PKC (protein kinase C) belongs to AGC group. PKC can be grouped into three sections based on similar structural and activation requirements: classical, novel and atypical. Classical PKCs are activated by calcium, phosphatidylserine and diacylglycerol or phorbol esters. The novel PKCs lack a conserved region found in classical PKC and is activated by different lipids. The atypical PKCs is smallest in size in all PKCs which are activated by PS. PKCs keep an inactive state in the cytosol and translocate to the membrane vesicles, nuclear structures and cytoskeletal components after cell stimulation. Activated PKCs have been shown to involve in a varieties cellular processes including receptor desensitization, transcription, immune responses and cell growth (1).

Reference
1. Keenan, C. and Kelleher, D. (1998) Protein kinase C and the cytoskeleton. Cell Signal, 10, 225-232. PMID: 9617479


There are 9 genes.  Reviewed (0 or Unreviewed (9

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Pes-0354
ENSPSIG00000015493.1
K7GB76
2
iEKPD-Pes-0373
ENSPSIG00000016217.1
K7GDN9
PRKCA
3
iEKPD-Pes-0057
ENSPSIG00000004330.1
K7F9H3
PRKCB
4
iEKPD-Pes-1179
ENSPSIG00000017087.1
K7GGE9
PRKCD
5
iEKPD-Pes-0256
ENSPSIG00000011478.1
K7FXV6
PRKCE
6
iEKPD-Pes-0260
ENSPSIG00000011692.1
K7FYV7
PRKCH
7
iEKPD-Pes-0283
ENSPSIG00000012576.1
K7G1M2
PRKCI
8
iEKPD-Pes-1163
ENSPSIG00000009425.1
K7FRE0
PRKCQ
9
iEKPD-Pes-0133
ENSPSIG00000007357.1
K7FJG4
PRKCZ