※ PKC family introduction

    PKC (protein kinase C) belongs to AGC group. PKC can be grouped into three sections based on similar structural and activation requirements: classical, novel and atypical. Classical PKCs are activated by calcium, phosphatidylserine and diacylglycerol or phorbol esters. The novel PKCs lack a conserved region found in classical PKC and is activated by different lipids. The atypical PKCs is smallest in size in all PKCs which are activated by PS. PKCs keep an inactive state in the cytosol and translocate to the membrane vesicles, nuclear structures and cytoskeletal components after cell stimulation. Activated PKCs have been shown to involve in a varieties cellular processes including receptor desensitization, transcription, immune responses and cell growth (1).

Reference
1. Keenan, C. and Kelleher, D. (1998) Protein kinase C and the cytoskeleton. Cell Signal, 10, 225-232. PMID: 9617479

  Reviewed (0)  or Unreviewed (8) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sah-0128	ENSSHAG00000007558.1	G3VZX3
2		iEKPD-Sah-0176	ENSSHAG00000009585.1	G3W6T1	PRKCA
3		iEKPD-Sah-0162	ENSSHAG00000008514.1	G3W328	PRKCB
4		iEKPD-Sah-1170	ENSSHAG00000008499.1	G3W312	PRKCD
5		iEKPD-Sah-0158	ENSSHAG00000008401.1	G3W2Q1	PRKCG
6		iEKPD-Sah-0196	ENSSHAG00000010229.1	G3W917	PRKCH
7		iEKPD-Sah-0340	ENSSHAG00000015052.1	G3WQL9	PRKCI
8		iEKPD-Sah-1183	ENSSHAG00000014158.1	G3WMI8	PRKCQ