※ PKC family introduction

    PKC (protein kinase C) belongs to AGC group. PKC can be grouped into three sections based on similar structural and activation requirements: classical, novel and atypical. Classical PKCs are activated by calcium, phosphatidylserine and diacylglycerol or phorbol esters. The novel PKCs lack a conserved region found in classical PKC and is activated by different lipids. The atypical PKCs is smallest in size in all PKCs which are activated by PS. PKCs keep an inactive state in the cytosol and translocate to the membrane vesicles, nuclear structures and cytoskeletal components after cell stimulation. Activated PKCs have been shown to involve in a varieties cellular processes including receptor desensitization, transcription, immune responses and cell growth (1).

Reference
1. Keenan, C. and Kelleher, D. (1998) Protein kinase C and the cytoskeleton. Cell Signal, 10, 225-232. PMID: 9617479

  Reviewed (0)  or Unreviewed (10) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sus-0297	ENSSSCG00000017268.3	F1RV14
2		iEKPD-Sus-0403	ENSSSCG00000031428.1	A0A286ZQP3
3		iEKPD-Sus-0423	ENSSSCG00000033674.1	K9J4L8	PRKCB_tv2
4		iEKPD-Sus-1287	ENSSSCG00000023503.2	A0A287A287	PRKCD
5		iEKPD-Sus-0125	ENSSSCG00000008444.3	F1S5K7	PRKCE
6		iEKPD-Sus-0047	ENSSSCG00000003256.3	F1RNJ0	PRKCG
7		iEKPD-Sus-0079	ENSSSCG00000005095.3	F1SRU7	PRKCH
8		iEKPD-Sus-0203	ENSSSCG00000011745.3	F1SH28	PRKCI
9		iEKPD-Sus-1277	ENSSSCG00000011131.3	A0A287AH32	PRKCQ
10		iEKPD-Sus-0388	ENSSSCG00000030361.2	A0A286ZSY3	PRKCZ