※ PKC family introduction

    PKC (protein kinase C) belongs to AGC group. PKC can be grouped into three sections based on similar structural and activation requirements: classical, novel and atypical. Classical PKCs are activated by calcium, phosphatidylserine and diacylglycerol or phorbol esters. The novel PKCs lack a conserved region found in classical PKC and is activated by different lipids. The atypical PKCs is smallest in size in all PKCs which are activated by PS. PKCs keep an inactive state in the cytosol and translocate to the membrane vesicles, nuclear structures and cytoskeletal components after cell stimulation. Activated PKCs have been shown to involve in a varieties cellular processes including receptor desensitization, transcription, immune responses and cell growth (1).

Reference
1. Keenan, C. and Kelleher, D. (1998) Protein kinase C and the cytoskeleton. Cell Signal, 10, 225-232. PMID: 9617479

  Reviewed (0)  or Unreviewed (9) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Tag-0132	ENSTGUG00000003908.1	H0Z0E9
2		iEKPD-Tag-0465	ENSTGUG00000015253.1	H0ZYD1
3		iEKPD-Tag-0144	ENSTGUG00000004257.1	H0Z1Q4	PRKCA
4		iEKPD-Tag-0202	ENSTGUG00000006215.1	H0Z757	PRKCB
5		iEKPD-Tag-1283	ENSTGUG00000004544.1	H0Z2C3	PRKCD
6		iEKPD-Tag-0383	ENSTGUG00000012981.1	H0ZRX4	PRKCH
7		iEKPD-Tag-0327	ENSTGUG00000010959.1	H0ZL30	PRKCI
8		iEKPD-Tag-0078	ENSTGUG00000002037.1	H0YUY9	PRKCQ
9		iEKPD-Tag-0100	ENSTGUG00000002957.1	H0YXM1	PRKCZ