※ PKC family introduction

    PKC (protein kinase C) belongs to AGC group. PKC can be grouped into three sections based on similar structural and activation requirements: classical, novel and atypical. Classical PKCs are activated by calcium, phosphatidylserine and diacylglycerol or phorbol esters. The novel PKCs lack a conserved region found in classical PKC and is activated by different lipids. The atypical PKCs is smallest in size in all PKCs which are activated by PS. PKCs keep an inactive state in the cytosol and translocate to the membrane vesicles, nuclear structures and cytoskeletal components after cell stimulation. Activated PKCs have been shown to involve in a varieties cellular processes including receptor desensitization, transcription, immune responses and cell growth (1).

Reference
1. Keenan, C. and Kelleher, D. (1998) Protein kinase C and the cytoskeleton. Cell Signal, 10, 225-232. PMID: 9617479

  Reviewed (0)  or Unreviewed (12) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Tar-0011	ENSTRUG00000000339.1	H2RKW9
2		iEKPD-Tar-0139	ENSTRUG00000004569.1	H2SEN5
3		iEKPD-Tar-0333	ENSTRUG00000010099.1	H2TL80
4		iEKPD-Tar-0160	ENSTRUG00000005119.1	H2SIN2	LOC101063530
5		iEKPD-Tar-0315	ENSTRUG00000009582.1	H2THC6	LOC101065234
6		iEKPD-Tar-0027	ENSTRUG00000000911.1	H2RPU2	PRKCA (1 of many)
7		iEKPD-Tar-0516	ENSTRUG00000016241.1	H2UX35	PRKCA (1 of many)
8		iEKPD-Tar-0351	ENSTRUG00000010650.1	H2TQC3	prkcd
9		iEKPD-Tar-0148	ENSTRUG00000004772.1	H2SG44	prkce
10		iEKPD-Tar-0378	ENSTRUG00000011406.1	H2TVV2	prkch
11		iEKPD-Tar-0176	ENSTRUG00000005596.1	H2SM61	prkci
12		iEKPD-Tar-1502	ENSTRUG00000011933.1	H2TZU4	prkcq