※ PKC family introduction

    PKC (protein kinase C) belongs to AGC group. PKC can be grouped into three sections based on similar structural and activation requirements: classical, novel and atypical. Classical PKCs are activated by calcium, phosphatidylserine and diacylglycerol or phorbol esters. The novel PKCs lack a conserved region found in classical PKC and is activated by different lipids. The atypical PKCs is smallest in size in all PKCs which are activated by PS. PKCs keep an inactive state in the cytosol and translocate to the membrane vesicles, nuclear structures and cytoskeletal components after cell stimulation. Activated PKCs have been shown to involve in a varieties cellular processes including receptor desensitization, transcription, immune responses and cell growth (1).

Reference
1. Keenan, C. and Kelleher, D. (1998) Protein kinase C and the cytoskeleton. Cell Signal, 10, 225-232. PMID: 9617479

  Reviewed (0)  or Unreviewed (14) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Ten-0077	ENSTNIG00000003227.1	H3CC37
2		iEKPD-Ten-0136	ENSTNIG00000004949.1	H3C6F2
3		iEKPD-Ten-0149	ENSTNIG00000005329.1	H3CID4
4		iEKPD-Ten-0150	ENSTNIG00000005453.1	H3CIR6
5		iEKPD-Ten-0242	ENSTNIG00000008102.1	H3CRP3
6		iEKPD-Ten-0296	ENSTNIG00000009867.1	H3CWX1
7		iEKPD-Ten-0332	ENSTNIG00000011122.1	H3D0M1
8		iEKPD-Ten-0340	ENSTNIG00000011612.1	H3D224
9		iEKPD-Ten-0372	ENSTNIG00000012644.1	H3D527
10		iEKPD-Ten-0441	ENSTNIG00000014600.1	H3DAT6
11		iEKPD-Ten-0456	ENSTNIG00000014911.1	H3DBR2
12		iEKPD-Ten-0546	ENSTNIG00000017340.1	H3DIY4
13		iEKPD-Ten-0422	ENSTNIG00000014129.1	H3D9E7	PRKCA (1 of many)
14		iEKPD-Ten-0569	ENSTNIG00000017985.1	H3DKV1	PRKCA (1 of many)