※ PKG family introduction

    PKG (cGMP-dependent protein kinase) belongs to AGC group. Two genes have been identified in mammalian cells. The alternative splicing of the first two exons encoding the N-terminal of PKG-I cause the two isoforms, known as PKG-Iα and PKG-Iβ, PKG-Iα can be activated in a lower concentrations compared with PKG-Iβ, PKG-Iα and PKG-Iβ contain the different substrate specificity, which is meidated by the N-terminal domain. PKGs are activated downstream of cGMP signaling pathway and activated PKGs involve in a varieties of cellular processes via mediating phosphorylation of different proteins including platelet activation and adhesion, sooth muscle contraction, cardiac function and gene expressing (1).

Reference
1. Casteel, D.E., Zhang, T., Zhuang, S. and Pilz, R.B. (2008) cGMP-dependent protein kinase anchoring by IRAG regulates its nuclear translocation and transcriptional activity. Cell Signal, 20, 1392-1399. PMID: 18450420

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Dar-0162	ENSDARG00000020656.8	Q7T2E5	prkg1a
2		iEKPD-Dar-0221	ENSDARG00000031702.9	F1R125	prkg1b
3		iEKPD-Dar-0452	ENSDARG00000068026.5	E7F992	prkg1l
4		iEKPD-Dar-0334	ENSDARG00000054741.3	A0A286Y9K1	prkg2
5		iEKPD-Dar-0438	ENSDARG00000062839.5	E7FGA3	prkg2l
6		iEKPD-Dar-0100	ENSDARG00000014232.8	A0A0R4IVJ6	si:dkey-121j17.5