※ PKN family introduction

    PKN, also known as protein kinase C related kinase, belongs to the AGC group. PKNs are Serine/Threonine protein kinases which share a C-terminal catalytic domain homologous to PKC members and a N-terminal unique regulatory region containing antiparallel coiled-coil domains (ACC domains). AGC domains act as binding interface associated with others proteins including anchoring protein CG-NAP. Between the C-terminal and N-terminal region, a C2-like region can be found in PKNs, which functions as an auto-inhibitory region. PKN localizes primarily in the cytosolic fraction and is involved in a variety of cellular processes, including cytoskeletal regulation, cell adhesion, glucose transport, regulation of meiotic maturation and embryonic cell cycles and tumorigenesis (1).

Reference
1. Mukai, H. (2003) The structure and function of PKN, a protein kinase having a catalytic domain homologous to that of PKC. J Biochem, 133, 17-27. PMID: 12761194

  Reviewed (1)  or Unreviewed (4) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Dar-0883	ENSDARG00000101293.1	A7MBL8	pkn2
2		iEKPD-Dar-0410	ENSDARG00000060184.8	F6NV75	pkn1a
3		iEKPD-Dar-0437	ENSDARG00000062748.5	F1QXD6	pkn1b
4		iEKPD-Dar-0895	ENSDARG00000101983.1	A0A0R4IJZ0	pkn2
5		iEKPD-Dar-0582	ENSDARG00000079585.3	E7F7I3	pkn3