※ PKN family introduction

    PKN, also known as protein kinase C related kinase, belongs to the AGC group. PKNs are Serine/Threonine protein kinases which share a C-terminal catalytic domain homologous to PKC members and a N-terminal unique regulatory region containing antiparallel coiled-coil domains (ACC domains). AGC domains act as binding interface associated with others proteins including anchoring protein CG-NAP. Between the C-terminal and N-terminal region, a C2-like region can be found in PKNs, which functions as an auto-inhibitory region. PKN localizes primarily in the cytosolic fraction and is involved in a variety of cellular processes, including cytoskeletal regulation, cell adhesion, glucose transport, regulation of meiotic maturation and embryonic cell cycles and tumorigenesis (1).

Reference
1. Mukai, H. (2003) The structure and function of PKN, a protein kinase having a catalytic domain homologous to that of PKC. J Biochem, 133, 17-27. PMID: 12761194

  Reviewed (0)  or Unreviewed (5) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Gaa-0174	ENSGACG00000006215.1	G3NSB4
2		iEKPD-Gaa-0455	ENSGACG00000015702.1	G3PSZ2
3		iEKPD-Gaa-0522	ENSGACG00000018428.1	G3Q3C0
4		iEKPD-Gaa-0543	ENSGACG00000019310.1	G3Q6L6
5		iEKPD-Gaa-0429	ENSGACG00000014787.1	G3PPJ4	PKN3 (1 of many)