※ PKN family introduction

    PKN, also known as protein kinase C related kinase, belongs to the AGC group. PKNs are Serine/Threonine protein kinases which share a C-terminal catalytic domain homologous to PKC members and a N-terminal unique regulatory region containing antiparallel coiled-coil domains (ACC domains). AGC domains act as binding interface associated with others proteins including anchoring protein CG-NAP. Between the C-terminal and N-terminal region, a C2-like region can be found in PKNs, which functions as an auto-inhibitory region. PKN localizes primarily in the cytosolic fraction and is involved in a variety of cellular processes, including cytoskeletal regulation, cell adhesion, glucose transport, regulation of meiotic maturation and embryonic cell cycles and tumorigenesis (1).

Reference
1. Mukai, H. (2003) The structure and function of PKN, a protein kinase having a catalytic domain homologous to that of PKC. J Biochem, 133, 17-27. PMID: 12761194

  Reviewed (0)  or Unreviewed (3) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Loa-0408	ENSLAFG00000022604.2	G3UF16	PKN1
2		iEKPD-Loa-0228	ENSLAFG00000010893.3	G3T6G6	PKN2
3		iEKPD-Loa-0206	ENSLAFG00000009776.3	G3UKN4	PKN3