Ailuropoda melanoleuca      AGC/RSK


※ RSK family introduction

    RSK kinase is part of the mammalian target of rapamycin (mTOR) pathway which is a key regulator of cell growth via the regulation of protein synthesis. Both S6 kinase and eukaryotic initiation factor 4E-binding protein 1 (4EBP-1) are key mTOR effectors of cell growth. S6 kinase specifically phosphorylates ribosomal protein S6 in response to insulin or several classes of mitogens. S6 kinase is activated by Serine/Threonine phosphorylation and protein kinase C, and is inactivated by type 2A phosphatase. S6 kinase interacts with PPP1R9A/neurabin-1 (1).

Reference

1. InterPro Annotation: Ribosomal protein S6 kinase


There are 8 genes.  Reviewed (0 or Unreviewed (8

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Aim-0248
ENSAMEG00000010620.1
G1LW37
RPS6KA1
2
iEKPD-Aim-0221
ENSAMEG00000009322.1
G1LRZ8
RPS6KA2
3
iEKPD-Aim-0391
ENSAMEG00000016514.1
G1MDV3
RPS6KA3
4
iEKPD-Aim-0435
ENSAMEG00000017931.1
G1MHW1
RPS6KA4
5
iEKPD-Aim-0043
ENSAMEG00000001721.1
G1L4Q5
RPS6KA5
6
iEKPD-Aim-0100
ENSAMEG00000003648.1
G1LAD8
RPS6KA6
7
iEKPD-Aim-0262
ENSAMEG00000011391.1
D2HLU3
RPS6KB1
8
iEKPD-Aim-0024
ENSAMEG00000000822.1
G1L1X5
RPS6KB2