※ RSK family introduction

    RSK kinase is part of the mammalian target of rapamycin (mTOR) pathway which is a key regulator of cell growth via the regulation of protein synthesis. Both S6 kinase and eukaryotic initiation factor 4E-binding protein 1 (4EBP-1) are key mTOR effectors of cell growth. S6 kinase specifically phosphorylates ribosomal protein S6 in response to insulin or several classes of mitogens. S6 kinase is activated by Serine/Threonine phosphorylation and protein kinase C, and is inactivated by type 2A phosphatase. S6 kinase interacts with PPP1R9A/neurabin-1 (1).

Reference

1. InterPro Annotation: Ribosomal protein S6 kinase

  Reviewed (0)  or Unreviewed (14) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Amt-0216	AMTR_s00022p00051940	W1PTQ0	AMTR_s00022p00051940
2		iEKPD-Amt-0237	AMTR_s00022p00236150	W1PUK0	AMTR_s00022p00236150
3		iEKPD-Amt-0241	AMTR_s00023p00186390	W1NIS0	AMTR_s00023p00186390
4		iEKPD-Amt-0279	AMTR_s00028p00241950	W1PSM7	AMTR_s00028p00241950
5		iEKPD-Amt-0320	AMTR_s00033p00229200	U5D1Z6	AMTR_s00033p00229200
6		iEKPD-Amt-0335	AMTR_s00040p00181290	W1PZU0	AMTR_s00040p00181290
7		iEKPD-Amt-0382	AMTR_s00049p00198350	W1Q0W4	AMTR_s00049p00198350
8		iEKPD-Amt-0395	AMTR_s00054p00182460	U5D6V0	AMTR_s00054p00182460
9		iEKPD-Amt-0476	AMTR_s00068p00198560	U5DGE8	AMTR_s00068p00198560
10		iEKPD-Amt-0483	AMTR_s00069p00188850	U5DGA8	AMTR_s00069p00188850
11		iEKPD-Amt-0541	AMTR_s00081p00063880	W1PA53	AMTR_s00081p00063880
12		iEKPD-Amt-0566	AMTR_s00092p00027310	W1NQH8	AMTR_s00092p00027310
13		iEKPD-Amt-0606	AMTR_s00111p00126010	W1NZX1	AMTR_s00111p00126010
14		iEKPD-Amt-0626	AMTR_s00133p00046270	W1P9W1	AMTR_s00133p00046270