Bos taurus      AGC/RSK


※ RSK family introduction

    RSK kinase is part of the mammalian target of rapamycin (mTOR) pathway which is a key regulator of cell growth via the regulation of protein synthesis. Both S6 kinase and eukaryotic initiation factor 4E-binding protein 1 (4EBP-1) are key mTOR effectors of cell growth. S6 kinase specifically phosphorylates ribosomal protein S6 in response to insulin or several classes of mitogens. S6 kinase is activated by Serine/Threonine phosphorylation and protein kinase C, and is inactivated by type 2A phosphatase. S6 kinase interacts with PPP1R9A/neurabin-1 (1).

Reference

1. InterPro Annotation: Ribosomal protein S6 kinase


There are 7 genes.  Reviewed (1 or Unreviewed (6

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Bot-0316
ENSBTAG00000016851.5
Q6TJY3
RPS6KB1
2
iEKPD-Bot-0270
ENSBTAG00000014447.4
A4IFF4
RPS6KA1
3
iEKPD-Bot-0334
ENSBTAG00000017639.4
F1MZW8
RPS6KA3
4
iEKPD-Bot-0440
ENSBTAG00000039153.2
F1MQE1
RPS6KA4
5
iEKPD-Bot-0198
ENSBTAG00000010906.5
E1BN61
RPS6KA5
6
iEKPD-Bot-0041
ENSBTAG00000002015.4
G5E5T2
RPS6KA6
7
iEKPD-Bot-0160
ENSBTAG00000009175.4
E1BLQ5
RPS6KB2