Caenorhabditis elegans      AGC/RSK


※ RSK family introduction

    RSK kinase is part of the mammalian target of rapamycin (mTOR) pathway which is a key regulator of cell growth via the regulation of protein synthesis. Both S6 kinase and eukaryotic initiation factor 4E-binding protein 1 (4EBP-1) are key mTOR effectors of cell growth. S6 kinase specifically phosphorylates ribosomal protein S6 in response to insulin or several classes of mitogens. S6 kinase is activated by Serine/Threonine phosphorylation and protein kinase C, and is inactivated by type 2A phosphatase. S6 kinase interacts with PPP1R9A/neurabin-1 (1).

Reference

1. InterPro Annotation: Ribosomal protein S6 kinase


There are 5 genes.  Reviewed (3 or Unreviewed (2

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Cae-0219
WBGene00011352
Q21734
rskn-1
2
iEKPD-Cae-0178
WBGene00008311
Q18846
rskn-2
3
iEKPD-Cae-0239
WBGene00012929
Q9NAH6
rsks-1
4
iEKPD-Cae-0294
WBGene00016980
G4S4W1
C56G2.5
5
iEKPD-Cae-0389
WBGene00044281
Q21694
CELE_R04A9.7