Canis familiaris      AGC/RSK


※ RSK family introduction

    RSK kinase is part of the mammalian target of rapamycin (mTOR) pathway which is a key regulator of cell growth via the regulation of protein synthesis. Both S6 kinase and eukaryotic initiation factor 4E-binding protein 1 (4EBP-1) are key mTOR effectors of cell growth. S6 kinase specifically phosphorylates ribosomal protein S6 in response to insulin or several classes of mitogens. S6 kinase is activated by Serine/Threonine phosphorylation and protein kinase C, and is inactivated by type 2A phosphatase. S6 kinase interacts with PPP1R9A/neurabin-1 (1).

Reference

1. InterPro Annotation: Ribosomal protein S6 kinase


There are 7 genes.  Reviewed (0 or Unreviewed (7

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Caf-0269
ENSCAFG00000012408.4
F1PIL4
RPS6KA1
2
iEKPD-Caf-0019
ENSCAFG00000000828.3
F6UWI0
RPS6KA2
3
iEKPD-Caf-0295
ENSCAFG00000013171.3
E2RP04
RPS6KA3
4
iEKPD-Caf-0465
ENSCAFG00000031793.1
F1PH63
RPS6KA4
5
iEKPD-Caf-0375
ENSCAFG00000017373.3
F1PV71
RPS6KA6
6
iEKPD-Caf-0382
ENSCAFG00000017679.3
E2RMD8
RPS6KB1
7
iEKPD-Caf-0249
ENSCAFG00000011590.4
E2R7K9
RPS6KB2