※ RSK family introduction

    RSK kinase is part of the mammalian target of rapamycin (mTOR) pathway which is a key regulator of cell growth via the regulation of protein synthesis. Both S6 kinase and eukaryotic initiation factor 4E-binding protein 1 (4EBP-1) are key mTOR effectors of cell growth. S6 kinase specifically phosphorylates ribosomal protein S6 in response to insulin or several classes of mitogens. S6 kinase is activated by Serine/Threonine phosphorylation and protein kinase C, and is inactivated by type 2A phosphatase. S6 kinase interacts with PPP1R9A/neurabin-1 (1).

Reference

1. InterPro Annotation: Ribosomal protein S6 kinase

  Reviewed (0)  or Unreviewed (6) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Cas-0076	ENSTSYG00000003062.2	A0A1U7UM12	RPS6KA1
2		iEKPD-Cas-0280	ENSTSYG00000012466.2	A0A1U7U8F8	RPS6KA3
3		iEKPD-Cas-0297	ENSTSYG00000013264.2	A0A1U7U1R1	RPS6KA5
4		iEKPD-Cas-0184	ENSTSYG00000007849.2	A0A1U7UEK7	RPS6KA6
5		iEKPD-Cas-0056	ENSTSYG00000002384.2	A0A1U7U9T8	RPS6KB1
6		iEKPD-Cas-0344	ENSTSYG00000027147.1	A0A1U7T5X1	RPS6KB2