※ RSK family introduction

    RSK kinase is part of the mammalian target of rapamycin (mTOR) pathway which is a key regulator of cell growth via the regulation of protein synthesis. Both S6 kinase and eukaryotic initiation factor 4E-binding protein 1 (4EBP-1) are key mTOR effectors of cell growth. S6 kinase specifically phosphorylates ribosomal protein S6 in response to insulin or several classes of mitogens. S6 kinase is activated by Serine/Threonine phosphorylation and protein kinase C, and is inactivated by type 2A phosphatase. S6 kinase interacts with PPP1R9A/neurabin-1 (1).

Reference

1. InterPro Annotation: Ribosomal protein S6 kinase

  Reviewed (0)  or Unreviewed (5) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Cym-0013	CMF118C	M1VFX1	CYME_CMF118C
2		iEKPD-Cym-0026	CML228C	M1V5K3	CYME_CML228C
3		iEKPD-Cym-0057	CMR193C	M1VB39	CYME_CMR193C
4		iEKPD-Cym-0072	CMT297C	M1VMJ4	CYME_CMT297C
5		iEKPD-Cym-0074	CMT328C	M1VCP3	CYME_CMT328C