Equus caballus      AGC/RSK


※ RSK family introduction

    RSK kinase is part of the mammalian target of rapamycin (mTOR) pathway which is a key regulator of cell growth via the regulation of protein synthesis. Both S6 kinase and eukaryotic initiation factor 4E-binding protein 1 (4EBP-1) are key mTOR effectors of cell growth. S6 kinase specifically phosphorylates ribosomal protein S6 in response to insulin or several classes of mitogens. S6 kinase is activated by Serine/Threonine phosphorylation and protein kinase C, and is inactivated by type 2A phosphatase. S6 kinase interacts with PPP1R9A/neurabin-1 (1).

Reference

1. InterPro Annotation: Ribosomal protein S6 kinase


There are 6 genes.  Reviewed (0 or Unreviewed (6

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Eqc-0252
ENSECAG00000016238.1
F6RWB8
RPS6KA1
2
iEKPD-Eqc-0157
ENSECAG00000011322.1
F6RET3
RPS6KA3
3
iEKPD-Eqc-0288
ENSECAG00000018402.1
F7AVS6
RPS6KA4
4
iEKPD-Eqc-0309
ENSECAG00000019431.1
F7DGR6
RPS6KA6
5
iEKPD-Eqc-0199
ENSECAG00000013890.1
F7D5V6
RPS6KB1
6
iEKPD-Eqc-0176
ENSECAG00000012221.1
F6Q7I1
RPS6KB2