Homo sapiens      AGC/RSK


※ RSK family introduction

    RSK kinase is part of the mammalian target of rapamycin (mTOR) pathway which is a key regulator of cell growth via the regulation of protein synthesis. Both S6 kinase and eukaryotic initiation factor 4E-binding protein 1 (4EBP-1) are key mTOR effectors of cell growth. S6 kinase specifically phosphorylates ribosomal protein S6 in response to insulin or several classes of mitogens. S6 kinase is activated by Serine/Threonine phosphorylation and protein kinase C, and is inactivated by type 2A phosphatase. S6 kinase interacts with PPP1R9A/neurabin-1 (1).

Reference

1. InterPro Annotation: Ribosomal protein S6 kinase


There are 8 genes.  Reviewed (8 or Unreviewed (0

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Hos-0168
ENSG00000117676.13
Q15418
RPS6KA1; MAPKAPK1A; RSK1
2
iEKPD-Hos-0057
ENSG00000071242.11
Q15349
RPS6KA2; MAPKAPK1C; RSK3
3
iEKPD-Hos-0390
ENSG00000177189.12
P51812
RPS6KA3; ISPK1; MAPKAPK1B; RSK2
4
iEKPD-Hos-0316
ENSG00000162302.12
O75676
RPS6KA4; MSK2
5
iEKPD-Hos-0099
ENSG00000100784.10
O75582
RPS6KA5; MSK1
6
iEKPD-Hos-0061
ENSG00000072133.10
Q9UK32
RPS6KA6; RSK4
7
iEKPD-Hos-0135
ENSG00000108443.13
P23443
RPS6KB1; STK14A
8
iEKPD-Hos-0386
ENSG00000175634.14
Q9UBS0
RPS6KB2; STK14B