Monodelphis domestica      AGC/RSK


※ RSK family introduction

    RSK kinase is part of the mammalian target of rapamycin (mTOR) pathway which is a key regulator of cell growth via the regulation of protein synthesis. Both S6 kinase and eukaryotic initiation factor 4E-binding protein 1 (4EBP-1) are key mTOR effectors of cell growth. S6 kinase specifically phosphorylates ribosomal protein S6 in response to insulin or several classes of mitogens. S6 kinase is activated by Serine/Threonine phosphorylation and protein kinase C, and is inactivated by type 2A phosphatase. S6 kinase interacts with PPP1R9A/neurabin-1 (1).

Reference

1. InterPro Annotation: Ribosomal protein S6 kinase


There are 7 genes.  Reviewed (0 or Unreviewed (7

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Mod-0296
ENSMODG00000014283.3
F6X0J4
RPS6KA1
2
iEKPD-Mod-0149
ENSMODG00000008086.3
F6YJ34
RPS6KA3
3
iEKPD-Mod-0433
ENSMODG00000021146.3
H9H7V4
RPS6KA4
4
iEKPD-Mod-0056
ENSMODG00000002626.3
F7FUC1
RPS6KA5
5
iEKPD-Mod-0297
ENSMODG00000014302.3
F6W4N6
RPS6KA6
6
iEKPD-Mod-0298
ENSMODG00000014313.3
F7BTW0
RPS6KB1
7
iEKPD-Mod-0136
ENSMODG00000007615.3
F7C5A4
RPS6KB2